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目的 探讨脑卒中患者载脂蛋白H(ApoH)血清水平与血脂的相关性以及ApoH与脑卒中的关系。方法 采用放射免疫法检测急性动脉粥样硬化性血栓性脑梗死 (ACI)患者 33例和急性高血压性脑出血 (ACH)患者 2 8例的ApoH血清水平 ,酶法测定血脂各项。结果 ACI、ACH患者与健康对照组血清ApoH水平分别为 2 88mg/L± 85 4mg/L、2 4 8mg/L± 6 8mg/L、2 5 6mg/L± 71mg/L。ACI患者的ApoH血清水平与胆固醇 (CHO)、低密度脂蛋白 (LDL)呈正相关 (r=0 394 ,P <0 0 5 ;r =0 394 ,P<0 0 5 ) ,与TG无相关性。 17例有家族史的脑卒中患者血清ApoH与高密度脂蛋白相关。结论 ApoH血清水平与ACI患者的CHO、LDL相关 ,与正常人及ACH患者无相关性。
Objective To investigate the correlation between serum levels of apolipoprotein H (ApoH) and blood lipids in stroke patients and the relationship between ApoH and stroke. Methods ApoH serum levels in 33 patients with acute atherothrombotic cerebral infarction (ACI) and 28 patients with acute hypertensive intracerebral hemorrhage (ACH) were measured by radioimmunoassay. Results The serum levels of ApoH in patients with ACI and ACH were 888 mg / L ± 85 4 mg / L, 248 mg / L ± 68 mg / L and 256 mg / L ± 71 mg / L, respectively. ApoH serum levels of ACI patients were positively correlated with cholesterol and low density lipoprotein (LDL) (r = 0 394, P <0 05; r = 0 394, P 0 05), but not with TG . Serum ApoH was associated with high density lipoprotein in 17 stroke patients with family history. Conclusion The serum level of ApoH is correlated with CHO and LDL in patients with ACI and no correlation with normal and ACH patients.