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关于正常及多囊卵巢综合征(pcos)妇女,胰岛素对血清雄激素作用的研究结果不甚一致。本文利用内源性胰岛素释放抑制剂——二氮嗪降低 pcos肥胖妇女血胰岛素水平,观察血清类固醇激素,性激素结合球蛋白(SHBG),LH、FSH 的改变,验证高胰岛素血症是高雄激素血症发病原因这一假说。受试者为5名肥胖 pcos 患者,肥胖指数(BMI)均大于28kg/m~2,其中2例伴黑棘皮症,口服糖耐量(OGTT)反应均正常。3例先行对照周期研究,28天后口服二氮嗪300mg/日共10天,另2例则按相反的顺序进行。研究日手臂静脉置肝素化导
In women with normal and polycystic ovary syndrome (pcos), the effect of insulin on serum androgen levels is less consistent. In this paper, the endogenous insulin release inhibitor diazoxide is used to reduce the blood insulin level in women with pcos obesity. The changes of serum steroid hormones, sex hormone binding globulin (SHBG), LH and FSH were observed. Hyperinsulinism Disease incidence of this hypothesis. Subjects were 5 obese patients with pcos, obesity index (BMI) were greater than 28kg / m ~ 2, of which 2 cases with acanthosis nigral, oral glucose tolerance (OGTT) response were normal. 3 cases of controlled trial of the first period, oral diazoxide 28 days after oral administration of 300mg / day for 10 days, and the other two cases in the reverse order. Study arm vein heparinization guide