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目的 :探讨基质金属蛋白酶 - 2和 - 9(MMP- 2和 MMP- 9)在膀胱癌组织的表达及其意义。方法 :应用免疫组织化学方法检测 40例非复发性膀胱癌、2 6例复发性膀胱癌、12例膀胱移行细胞乳头状瘤和 8例膀胱粘膜中 MMP- 2和 MMP- 9的表达水平 ,并比较二者与膀胱癌浸润深度、复发的关系。结果 :MMP- 2和 MMP- 9在膀胱癌的表达明显多于乳头状瘤和膀胱粘膜 (均 P<0 .0 1) ,且与癌组织的分化有一定的关系 ,分化差者 ,阳性率较高。未浸润肌层的膀胱癌 ,其 MMP- 2和 MMP- 9的表达明显低于浸润肌层及肌层以外者 (MMP- 2 :P<0 .0 1;MMP- 9:P<0 .0 5 ) ;二者的表达与膀胱癌复发也有明显的关系 ,复发者 ,阳性率较高 (P<0 .0 5 )。结论 :MMP- 2和 MMP- 9的表达与膀胱癌的浸润和复发有关 ,可作为预测复发和预后的有用标志物。
Objective: To investigate the expression and significance of matrix metalloproteinase - 2 and -9 (MMP - 2 and MMP - 9) in bladder cancer. Methods: The expressions of MMP-2 and MMP-9 in 40 cases of non-recurrent bladder cancer, 26 cases of recurrent bladder cancer, 12 cases of bladder transitional cell papillomatosis and 8 cases of bladder mucosa were detected by immunohistochemistry Compare the two with the depth of invasion, recurrence of bladder cancer. Results: The expression of MMP-2 and MMP-9 in bladder cancer was significantly higher than that in papilloma and bladder mucosa (all P <0.01), and had some relationship with the differentiation of cancer tissues. The poorly differentiated and positive rate Higher. The expression of MMP-2 and MMP-9 in bladder cancer without infiltrating muscular layer was significantly lower than those in the infiltrating muscular layer and muscular layer (MMP-2: P <0.01; MMP-9: P < 5). The expression of the two had a clear relationship with the recurrence of bladder cancer. The recurrence rate was higher (P <0.05). Conclusion: The expressions of MMP-2 and MMP-9 are correlated with the infiltration and recurrence of bladder cancer, which may be useful markers for predicting recurrence and prognosis.