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目的探讨咪达唑仑治疗小儿惊厥持续状态的临床疗效及安全性。方法将我院78例惊厥持续状态患儿随机分为地西泮治疗组(对照组)和咪达唑仑治疗组(观察组),每组各39例,比较两组患儿的临床疗效,观察不良反应。结果观察组患儿治疗后有效37例,无效2例,治疗有效率为94.9%,对照组治疗后有效29例,无效10例,治疗有效率为74.4%,治疗有效率组间差异有统计学意义(P<0.05)。观察组患儿治疗后未出现呼吸抑制及循环障碍,对照组患儿5例出现呼吸抑制,给予气管插管、呼吸机辅助治疗后症状缓解。结论采用咪达唑仑治疗小儿惊厥持续状态,临床疗效好,安全性高,值得临床进一步推广使用。
Objective To investigate the clinical efficacy and safety of midazolam in the treatment of persistent convulsions in children. Methods Seventy-eight children with convulsions in our hospital were randomly divided into diazepam-treated group (control group) and midazolam-treated group (observation group), 39 cases in each group. The clinical efficacy, Adverse reactions observed. Results In observation group, 37 cases were effective and 2 cases were ineffective after treatment. The effective rate was 94.9% in treatment group, 29 cases in control group after treatment, 10 cases were ineffective, and the effective rate was 74.4%. The difference between the two groups was statistically significant Significance (P <0.05). No respiratory depression and circulatory disturbance were found in the observation group after treatment. Respiratory depression was found in 5 cases in the control group, and the symptoms were relieved after intubation and ventilator-assisted therapy. Conclusion Midazolam treatment of convulsions in children with sustained state, good clinical efficacy, high safety, it is worth further clinical use.