对包括慢性肝炎、肝炎肝硬变和原发性肝癌在内的１００例慢性ＨＢＶ感染者作了ＨＢ－ｓＡｇ亚型分析。结果显示，在这组病例中ａｄｒ亚型占６１％，ａｄｗ占３３％，ａｙｒ占２％，ａｄｗｒ占４％。ａｄｒ亚型有随年龄增长更占优势的趋向。ａｄｒ和ａｄｗｒ亚型感染者ＨＢｓＡｇ滴度较ａｄｗ组显著增高，且ｅ抗原阳性率亦较高。上述发现提示，具有ａｄｒ和ａｄｗｒ亚型的ＨＢＶ株可能具有较强的复制活性，不易被清除，从而导致受感染者病程迁延。 HB-sAg subtypes were analyzed in 100 patients with chronic HBV infection, including chronic hepatitis, cirrhosis of the liver and primary liver cancer. The results showed that adr subtypes accounted for 61%, adw 33%, ayr 2%, and adwr 4% in this group. Adr subtypes tend to predominate with age. HBsAg titers in adr and adwr subtype were significantly higher than those in adw group, and e antigen positive rate was also higher. The above findings suggest that HBV strains with adr and adwr subtypes may have strong replication activity and are not easily cleared, resulting in prolonged course of disease in infected individuals.