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目的：通过对单纯性肥胖儿童血脂、红细胞膜脂及其流动性的研究，初步了解其脂代谢紊乱的状况，并探讨其动脉粥样硬化危险性增加的可能机制。方法：对筛选出的４９ 名肥胖儿童及其正常对照，测定其血清脂质、红细胞膜磷脂（ Ｐ Ｌ） 、膜胆固醇（ Ｃ Ｈ Ｏ） 及膜流动性（ Ｐ） 。结果：肥胖组儿童 Ｔ Ｇ、 Ｖ Ｌ Ｄ Ｌ Ｃ 的浓度、动脉粥样硬化指数（ Ａ Ｉ） 、 Ｌ Ｄ Ｌ Ｃ／ Ｈ Ｄ Ｌ Ｃ 比值均显著高于正常组（ Ｐ＜ ０ ．０５） ；而 Ｈ Ｄ Ｌ Ｃ 的浓度及 Ｈ Ｄ Ｌ Ｃ／ Ｔ Ｃ 比值则显著低于正常组（ Ｐ＜ ０ ．０５） ，但两组的 Ｔ Ｃ 含量无显著性差异。肥胖组儿童 Ｐ Ｌ 含量显著低于正常组（ Ｐ＜ ０ ．０５） ， Ｃ Ｈ Ｏ 和 Ｃ Ｈ Ｏ／ Ｐ Ｌ 比值显著高于正常组（ Ｐ＜ ０ ．０５） ；而 Ｐ 显著低于正常儿童。结论：单纯性肥胖症儿童血脂代谢出现紊乱，膜脂和膜流动性在血清胆固醇水平正常的情况下即出现异常变化，肥胖儿童脂代谢异常在红细胞膜脂质及其流动性方面可能比血脂更早表现出来，并对肥胖儿童 Ａ Ｓ的预测和预防可能会有更大的价值。
OBJECTIVE: To understand the status of dyslipidemia and to explore the possible mechanism of increased risk of atherosclerosis through the study of the lipid, erythrocyte membrane lipid and their fluidity in simple obese children. Methods: Forty-nine obese children and their normal controls were screened for serum lipids, phospholipids (P L), cholesterol (C H O) and membrane fluidity (P). Results: The concentrations of T G, V L D C, A atherosclerosis index and L D L-C / H D L-C in obese group were significantly higher than those in normal group (P <0. 05). However, the concentrations of H D L-C and H D L-C / T C were significantly lower than those of the normal group (P <0.05), but there was no significant difference between the two groups. The content of P L in obese group was significantly lower than that in normal group (P <0.05), and the ratio of C H O and C H O / P L was significantly higher than that in normal group (P <0.05) . Conclusions: The dyslipidemias in children with simple obesity are disturbed. The membrane lipid and membrane fluidity change abnormally when the level of serum cholesterol is normal. The dyslipidemia in obese children may be more lipid than liquid lipids in erythrocyte membrane As early as possible, and the prediction and prevention of obesity in children A S may be more valuable.