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目的探讨高级别脑胶质瘤患者术后单纯放疗与同步放化疗的疗效。方法本前瞻性研究共纳入116例患者,均于术后证实高级别胶质瘤,分为单纯放疗组与同步放化疗组,放疗均行三维适形放疗,总剂量60~64 Gy;同步放化疗组同时给予替莫唑胺同步化疗。结果同步放化疗组有效率优于单纯放疗组,分别为72.4%和44.8%,差异有统计学意义(P<0.05);同步放化疗组1、2年生存率分别为75.9%、65.5%,优于单纯放疗组的51.7%、41.4%(P<0.05)。结论高级别脑胶质瘤术后同步放化疗治疗更益于临床。
Objective To investigate the effect of simple radiotherapy and concurrent chemoradiotherapy in patients with high-grade gliomas. Methods A total of 116 patients were enrolled in this prospective study. High-grade gliomas were confirmed after operation. The patients were divided into radiotherapy group and concurrent chemoradiotherapy group. Radiotherapy underwent three-dimensional conformal radiotherapy with a total dose of 60 Gy to 64 Gy. Chemotherapy group also received temozolomide concurrent chemotherapy. Results The effective rate of concurrent chemoradiotherapy was 72.4% and 44.8% respectively, the difference was statistically significant (P <0.05). The 1- and 2-year survival rates of concurrent chemoradiotherapy group were 75.9% and 65.5% respectively, Which is superior to 51.7% and 41.4% of the radiotherapy alone group (P <0.05). Conclusions High grade glioma is more effective in clinical treatment after concurrent chemoradiotherapy.