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采用生长抑素250μg静脉推注再以250μg/h连续静脉滴注维持治疗肝硬化门静咏高压食管静脉曲张破裂出血的病人19例,16例在12h内出血停止,3例出血明显减少(仅有少量渗血)。待出血基本控制后再经内镜注射硬化剂,见胃及食管内潴留液很少,视野清晰,19例止血全部成功。应用生长抑素后食管静脉及门静脉宽度较应用前分别缩小38.3％及34.4％,均有显著性差异(t=7.52及7.90,均P<0.01)。减少胃液分泌和升高pH值疗效显著(t=39.3和5.83,均P<0.01)。未发现副作用。
19 patients with portal hypertension and esophageal variceal bleeding were treated with intravenous injection of somatostatin 250 μg and continuous intravenous infusion of 250 μg / h. 16 patients stopped bleeding within 12 h and significantly reduced bleeding in 3 patients A small amount of bleeding). To be basic control of bleeding after endoscopic injection of sclerosing agent, see the stomach and esophageal retention fluid rarely, clear vision, 19 cases of hemostasis were all successful. The esophageal and portal vein width decreased by 38.3% and 34.4% respectively after application of somatostatin (t = 7.52 and 7.90, both P <0.01). Reducing the secretion of gastric juice and increasing the pH value were significant (t = 39.3 and 5.83, both P <0.01). No side effects found.