目的观察健脾化瘀方联合介入手术用于肝癌肝移植复发患者的疗效及安全性。方法将204例肝癌肝移植后复发患者随机分为试验组和对照组各102例。2组均行介入治疗,试验组另辅以健脾化瘀方治疗。治疗后观察2组患者治疗效果及不良反应。结果试验组总有效率为91.18%高于对照组的74.51%,差异有统计学意义(P<0.05)。试验组患者治疗后3、6个月存活率及生存期均高于对照组,差异均有统计学意义(P<0.05)。试验组患者治疗后不良反应事件发生率为12.75%显著低于对照组的31.37%,差异有统计学意义(P<0.05)。结论健脾化瘀方联合介入手术治疗肝癌肝移植后患者具有良好的治疗效果和可靠的安全性,值得临床推广应用。 Objective To observe the efficacy and safety of Jianpi Huayu Decoction combined with interventional surgery in patients with liver cancer recurrence after liver transplantation. Methods 204 patients with liver cancer recurrence after liver transplantation were randomly divided into experimental group and control group of 102 cases. Interventional therapy was performed in both groups. The experimental group was additionally supplemented with Jianpi Huayu Recipe. After treatment, the treatment effect and adverse reactions in 2 groups were observed. Results The total effective rate of the experimental group was 91.18% higher than 74.51% of the control group, the difference was statistically significant (P <0.05). The survival rate and survival rate of experimental group were significantly higher than those of control group at 3 and 6 months after treatment, with significant difference (P <0.05). The incidence of adverse reactions after treatment in the experimental group was significantly lower than that in the control group (12.75% vs 31.37%, P <0.05). Conclusion Jianpi Huayu decoction combined with interventional surgery for patients with liver cancer after liver transplantation has good therapeutic effect and reliable safety, worthy of clinical application.