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早期临床实践发现，氯喹、奎纳克林、金鸡纳生物碱的抗疟作用只限于疟原虫生活史中能降解血红蛋白的阶段。红内期疟原虫对氯喹的敏感性与其血红蛋白的分解代谢程度一致。感染疟原虫的红细胞内，氯喹积聚的浓度远远超过未感染的红细胞内氯喹的浓度。Ｓｉｎｄｅｎ等［１］报...
Early clinical practice found that chloroquine, quinacrine, cinchona alkaloids antimalarial activity is limited to the life cycle of Plasmodium can degrade hemoglobin stage. The susceptibility of red blood Plasmodium to chloroquine is consistent with the degree of catabolism of hemoglobin. The concentration of chloroquine in erythrocytes infected with Plasmodium far exceeds the concentration of chloroquine in uninfected erythrocytes. Sinden et al [1] reported ...