自上世纪40年代使用第一个β-内酰胺类抗生素—青霉素以来,由于众多该类抗生素的滥用,细菌对其耐药性已成为临床治疗的一大威胁。β-内酰胺酶的产生是细菌对该类抗生素产生耐药的主要机制。为了战胜疾病,人类使用近似剂来克服β-内酰胺酶的破坏作用,使β-内酰胺酶失去活力,这就 Since the first β-lactam antibiotic, penicillin, was used in the 1940s, bacterial resistance to it has become a major threat to clinical management due to the abuse of many of these antibiotics. β-lactamase production is the main mechanism of bacterial resistance to such antibiotics. In order to overcome the disease, human use of similar agents to overcome the destructive effect of β-lactamase, β-lactamase loss of vitality, which