拉莫三嗪是一种新型抗癫痫药物,其抗癫痫谱广泛,美国食品药品管理局(FDA)批准的适应证包括多种部分性发作和全面性发作。与癫痫类似,偏头痛也是发作性疾病,以暂时性脑功能改变为特征,且研究表明两者发病机制中均存在离子通道过度活化及兴奋性氨基酸异常释放。近年来,多项临床试验均对抗癫痫药物在偏头痛预防和治疗等方面的应用进行了研究,研究结果令人鼓舞。循证医学证据显示拉莫三嗪能有效预防有先兆性偏头痛的发作。 Lamotrigine is a novel antiepileptic drug with a broad spectrum of anti-epilepsy. The FDA approved indications include multiple partial and full-blown episodes. Similar to epilepsy, migraine is also a seizure disorder characterized by transient brain function changes, and studies show that there is ion channel over-activation and excitatory amino acid abnormalities in both pathogenesis. In recent years, a number of clinical trials have been conducted on the application of antiepileptic drugs in the prevention and treatment of migraine and the results are encouraging. Evidence-based medical evidence shows that lamotrigine can effectively prevent the onset of migraine with aura.