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为观察北京生物制品研究所研制的纯化冻干Vero细胞流行性乙型脑炎灭活疫苗 (Vero细胞乙脑疫苗 )接种后的人体反应和免疫效果 ,在乙脑非疫区的内蒙古自治区伊金霍洛旗选取两所小学 6～ 8岁学龄儿童 ,按照补体结合抗原 1:8和 1:4两种抗原含量接种疫苗。设未接种疫苗的对照组。结果显示 :接种两种抗原含量的疫苗后未见接种局部反应和全身不适 ,仅 1 6 %～ 2 9%的儿童出现中度发热反应 ;基础免疫 2针 ,中和抗体阳转率分别为77 5 9%、89 5 8% ,中和抗体几何平均滴度 (GMT)分别为 1:14 96、1:16 75 ;3针的阳转率分别为 96 78%、10 0 0 0 % ,中和抗体GMT分别为 1:89 4 6、1:89 80。因此 ,1:8及 1:4两种抗原含量的Vero细胞乙脑疫苗人体接种反应轻微 ,免疫效果良好 ,均比现行应用的纯化地鼠肾细胞乙脑灭活疫苗免疫效果好
In order to observe the human response and immune effects after inoculation of the purified lyophilized Vero cell Japanese encephalitis inactivated vaccine (Vero cell JE vaccine) developed by Beijing Institute of Biological Products, Two primary school-aged children aged 6-8 years old were selected in HOROU, and vaccinated with two antigenic levels of complement-bound antigen 1: 8 and 1: 4. Set up the unvaccinated control group. The results showed that there was no local inoculation and systemic discomfort after inoculation of the two antigens, and only 16% -29% of the children showed moderate fever response. The 2 basal immunization and neutralization antibody positive rates were 77 The average geometric mean titers of neutralizing antibodies (GMTs) were 1:14 96 and 1:75 75, respectively. The positive rates of 3-stitches were 96 78% and 100 0%, respectively And antibody GMT were 1:89 4 6,1: 89 80 respectively. Therefore, the Vero cell JE vaccine with 1: 8 and 1: 4 antigen content had a slight human inoculation reaction and a good immune effect, which was better than that of the currently used purified mouse JE vaccine