基因敲除技术是一种新的生物遗传工程技术,在生物和医学领域的应用日趋广泛。维生素D通过维生素D受体的介导发挥多种生理作用,借助维生素D受体的基因敲除技术可更清楚地研究维生素D的多种生理功能,为以后的生物研究提供新的方向与方法。该文就基因敲除技术应用于维生素D受体后对机体肠道功能、抗肿瘤功能、心血管功能方面影响的研究进展作一综述。 Gene knockout technology is a new bioengineering engineering technology, which is widely used in biology and medicine. Vitamin D plays a variety of physiological roles through the mediation of vitamin D receptors. With the help of the gene knockout technology of vitamin D receptor, vitamin D can be more clearly studied on physiological functions and provide new directions and methods for future biological research . This review summarizes the research progress on the effect of gene knockdown on vitamin D receptor on the intestinal function, antitumor function and cardiovascular function in vivo.