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设计合成了２１个１［２（取代苯基甲硫基）２（２，４二氟苯基）乙基］１Ｈ１，２，４三唑类化合物，其中１９个为首次报道。体外抑菌试验表明：所有目标化合物对８种试验真菌均有不同程度的抗菌活性，其中化合物１，２，５对絮状表皮癣菌的活性为硫康唑的５１２倍以上；化合物５对白色念株菌的活性为硫康唑的３２倍；化合物２对申克孢子丝菌的活性为硫康唑的３２倍；化合物２，１４对新型隐球菌的活性分别为硫康唑的６４倍，３２倍；化合物１，５对熏烟色曲菌的活性分别为硫康唑的１６倍以上
Design and synthesis of 21 1 2 (substituted phenylmethylthio) 2 (2, 4 difluorophenyl) ethyl] 1 H 1, 2, 4 triazole compounds, of which 19 The first report. In vitro bacteriostatic test showed that all the target compounds had different degree of antibacterial activity against the eight tested fungi, of which compounds 1, 2 and 5 were more than 512 times more active against flocculant epidermis than sulconazole; The activity of Candida was 32 times that of Sulconazole; the activity of Compound 2 against Spirulina was 27 times that of Sulconazole; the activity of Compounds 2,14 against Cryptococcus neoformans was 64 times that of Sulconazole, 32 times; compound 1,5 on the fungus Aspergillus fumigatus were 16 times higher than that of sulconazole