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目的探讨两性霉素B脂质体联合氟康唑治疗早产儿真菌感染的疗效及安全性。方法收集2009.10—2011.5收治的中枢神经系统真菌感染早产儿7例,均应用两性霉素B脂质体联合氟康唑治疗,总疗程8～12周,监测治疗过程中患儿临床症状、体征及相关的血清学、脑脊液及影像学检查指标。结果两性霉素B脂质体联合氟康唑足量长疗程治疗使早产儿真菌感染得到良好控制,除1例放弃治疗外,余6例症状明显改善,血培养均转阴,中枢神经系统病灶较前明显改善。治疗过程中未发现较严重的药物不良反应。结论两性霉素B脂质体联合氟康唑治疗早产儿真菌性中枢感染有效且相对安全。
Objective To investigate the efficacy and safety of amphotericin B liposome combined with fluconazole in the treatment of fungal infection in premature infants. Methods 7 cases of central nervous system fungal infection in preterm infants admitted from 2009.10-2011.5 were collected. Both of them were treated with amphotericin B liposomes and fluconazole for a total duration of 8-12 weeks. The clinical symptoms, signs, Related serological, cerebrospinal fluid and imaging studies. Results Amphotericin liposomes combined with fluconazole sufficient long course of treatment of fungal infection in preterm children were well controlled, with the exception of 1 case of treatment, the other 6 cases were significantly improved, blood culture were negative, central nervous system lesions Compared with the previous significant improvement. No serious adverse drug reactions were found during the course of treatment. Conclusion amphotericin B liposomes combined with fluconazole treatment of fungal central infection in preterm children effective and relatively safe.