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目的探讨T淋巴瘤侵袭转移诱导基因1(Tiam1)表达与头颈部鳞状细胞癌浸润转移的关系。方法应用逆转录-PCR(RT-PCR)技术,对91例头颈部鳞状细胞癌组织和30例头颈部正常组织进行Tiam1 mRNA表达水平的检测,并结合临床特点进行分析。结果 Tiam1 mRNA在91例头颈部鳞状细胞癌组织中的表达水平明显高于头颈部正常组织,差异有统计学意义(P<0.01)。Tiam1 mRNA在淋巴结癌、扁桃体癌及中耳癌组织中的表达水平明显高于头颈部正常组织。Tiam1mRNA在不同分期、有无淋巴结转移的鼻咽癌、喉癌及上颌窦癌中的表达差异均有统计学意义(P<0.01)。结论 Tiam1 mRNA在头颈部鳞状细胞癌浸润转移过程中可能起重要作用,可成为判断头颈部鳞状细胞癌预后的指标之一。
Objective To investigate the relationship between the expression of Tiam1 in T lymphoma and invasion and metastasis of squamous cell carcinoma of head and neck. Methods The expression of Tiam1 mRNA in 91 cases of head and neck squamous cell carcinoma and 30 cases of normal tissues of head and neck were detected by reverse transcription-polymerase chain reaction (RT-PCR), and the clinical features were analyzed. Results The expression level of Tiam1 mRNA in 91 cases of head and neck squamous cell carcinoma tissues was significantly higher than that of head and neck normal tissues (P <0.01). The expression of Tiam1 mRNA in lymph node, tonsil and middle ear cancerous tissues was significantly higher than that in normal tissues of head and neck. There was significant difference in the expression of Tiam1mRNA in NPC, laryngeal cancer and maxillary sinus cancer with different stages and with or without lymph node metastasis (P <0.01). Conclusion Tiam1 mRNA may play an important role in the invasion and metastasis of squamous cell carcinoma of the head and neck and may be one of the prognostic indicators for squamous cell carcinoma of the head and neck.