一批甘露醇注射液出现大量结晶原因探讨

来源 :中国医院药学杂志 | 被引量 : 0次 | 上传用户:chenbin198718
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今年一月我院从医药公司购进江苏省某市药厂产甘露醇注射液1500瓶,规格250ml/瓶,批号861022.其中有结晶析出者141瓶,占总数的9.4%.为探讨出现大量结晶原因,我们将有结晶析出者温热溶解,然后对其进行澄明度检查,不溶性微粒检查、室温放置观察,并以本批号未有结晶析出者作对照.结果报告如下: In January of this year, our hospital purchased 1,500 bottles of mannitol injection from a pharmaceutical company in a pharmaceutical factory in Jiangsu Province in January of this year, with a specification of 250ml / bottle and lot number of 861022. Among them, 141 bottles were crystallized, accounting for 9.4% of the total. Crystallization reasons, we will have a crystalline precipitation dissolved warm, and then its clarity check, insoluble particulate inspection, placed at room temperature observation, and to the lot of no crystal precipitation as a control.The results are reported as follows:
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