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目的:研究胸部低剂量螺旋CT联合血清p16基因甲基化检测筛查早期肺癌的可行性。方法:本院体检的无症状肺癌高危人群共2332例按2:1随机分为2组,低剂量螺旋CT-p16组1555例,首先给予低剂量螺旋CT扫描,发现肺非钙化结节者行常规剂量CT及血清p16基因甲基化检测;标准剂量CT-p16组777例,给予标准剂量CT扫描,发现肺非钙化结节者行血清p16基因甲基化检测。结果:低剂量螺旋CT-p16组中11.4%及标准剂量CT-p16组12.1%患者可疑肺癌,其中低剂量螺旋CT-p16组中108例及标准剂量CT-p16组中50例确诊为肺癌。2组肺癌检出率比较差异无统计学意义(P>0.05)。结论:低剂量CT联合血清p16基因甲基化检测是一种敏感、安全、可行的筛查早期肺癌的方法。
Objective: To study the feasibility of low-dose chest CT combined with serum p16 gene methylation detection screening of early lung cancer. Methods: A total of 2332 high-risk patients with asymptomatic lung cancer who underwent physical examination in our hospital were randomly divided into 2 groups according to 2: 1. In the low-dose spiral CT-p16 group, 1555 patients were given low-dose spiral CT scans and found non-calcified nodules Routine dose CT and serum p16 gene methylation detection; 777 cases of standard dose CT-p16 group were given standard dose CT scan found non-calcified nodules lung serum p16 gene methylation detection. Results: In low-dose spiral CT-p16 group, 11.4% and 12.1% of patients in standard dose CT-p16 group were suspected of lung cancer. Among them, 108 cases in low-dose spiral CT-p16 group and 50 cases in standard dose CT-p16 group were diagnosed as lung cancer. There was no significant difference in the detection rate of lung cancer between the two groups (P> 0.05). Conclusion: Low-dose CT combined with serum p16 gene methylation detection is a sensitive, safe and feasible method for screening early lung cancer.