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目的 :探讨EB病毒感染与食管癌的相关性。方法 :采用免疫组织化学S P法 ,检测201例食管癌和100例食管良性病变粘膜组织中EBVLMP 1的表达。结果 :EBVLMP 1阳性率在食管癌组为29.85 % ,在食管良性病变粘膜组为2 % ,两组间有显著差异(P<0.001)EBVLMP 1的表达与食管癌的分化程度、淋巴结转移无关(P>0.05)。结论 :鼻咽癌高发区食管癌的发生与EBV感染有一定关系。
Objective: To explore the correlation between Epstein-Barr virus infection and esophageal cancer. Methods: Immunohistochemical SP method was used to detect the expression of EBVLMP 1 in 201 cases of esophageal cancer and 100 cases of benign esophageal mucosa. Results: The positive rate of EBVLMP 1 was 29.85% in esophageal cancer group and 2% in benign esophageal mucosa group, there was a significant difference between the two groups (P <0.001). EBVLMP 1 expression was not associated with the differentiation of esophageal cancer and lymph node metastasis P> 0.05). Conclusion: The incidence of esophageal cancer in high incidence area of nasopharyngeal carcinoma is related to EBV infection.