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WT1基因最早作为Wilms瘤的抑癌基因被发现 .近年来发现它在造血组织中也有表达 ,并与白血病的发生、发展及预后有关 .由于WT1在白血病中的表达有一定规律性 ,故可能成为微小残留白血病的检测标志 .现就WT1基因在白血病中的表达及其临床意义作一综述
The earliest WT1 gene was found to be the tumor suppressor gene of Wilms’ tumor and it was also found in hematopoietic tissues in recent years, which is related to the occurrence, development and prognosis of leukemia.As the expression of WT1 in leukemia has certain regularity, it may become Detection of Minimal Residual Leukemia: A Review of WT1 Gene Expression in Leukemia and Its Clinical Significance