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目的探析霉酚酸酯与环磷酰胺治疗系统性红斑狼疮的临床疗效。方法 50例系统性红斑狼疮患者,随机分为对照组(14例)和观察组(36例)。对照组给予环磷酰胺治疗,观察组给予霉酚酸酯治疗。对比分析两组的临床治疗效果。结果治疗后,观察组患者的血肌酐、血清白蛋白、24 h尿蛋白总量等均明显优于对照组,差异具有统计学意义(P<0.05);观察组的不良反应发生率为16.67%,明显优于对照组的64.29%,差异具有统计学意义(P<0.05)。结论相对于环磷酰胺,霉酚酸酯治疗系统性红斑狼疮的临床效果更好,且用药安全性更高,具有临床应用和推广价值。
Objective To investigate the clinical efficacy of mycophenolate mofetil and cyclophosphamide in the treatment of systemic lupus erythematosus. Methods Fifty patients with systemic lupus erythematosus were randomly divided into control group (n = 14) and observation group (n = 36). The control group was treated with cyclophosphamide, and the observation group was treated with mycophenolate mofetil. Comparative analysis of two groups of clinical treatment. Results After treatment, the levels of serum creatinine, serum albumin and 24 h urinary protein in the observation group were significantly better than those in the control group (P <0.05). The incidence of adverse reactions in the observation group was 16.67% , Which was significantly better than 64.29% of the control group, the difference was statistically significant (P <0.05). Conclusions Compared with cyclophosphamide, mycophenolate mofetil has better clinical efficacy and safety in treatment of systemic lupus erythematosus, which has clinical application and promotion value.