用均匀设计法设计苯乙烯和丙烯酸正丁酯的分散共聚合反应的试验,用DPS数据处理软件进行线性和二次逐步回归分析,建立聚合物粒子转化率、粒径及粒径分布这3个指标和各因素(单体总量及不同单体配比、稳定剂用量、引发剂用量、反应介质极性和温度)之间的回归方程,比较线性回归与二次回归的拟合度,考察各因素对3个指标影响的大小;然后用MATLAB软件优化二次回归方程,得到在约束条件下的最优配方和预测值,并进行实验验证。结果表明:二次回归方程的相关系数R=0.999997,明显优于线性回归的结果R=0.795144;各因素对3个指标的影响存在着交互作用,对各指标影响最显著的单因素及影响顺序如下:对转化率为引发剂用量>分散介质极性,对粒径大小为稳定剂用量>温度>单体中丙烯酸丁酯浓度>初始单体总质量;对粒径分布为分散介质极性>稳定剂浓度>温度;在最优配方下用二次回归方程得到的预测值与实验值之间各指标的误差分别为:转化率|△K|<0.6%,平均粒径|△(?)|<6%,粒子分散系数|△ε|<30%。 The uniform design method was used to design the experiment of the dispersion copolymerization of styrene and n-butyl acrylate. The linear and quadratic stepwise regression analysis was conducted with DPS data processing software to establish the polymer particle conversion, particle size and particle size distribution Indicators and various factors (total monomer and different monomer ratio, the amount of stabilizer, the amount of initiator, the reaction medium polarity and temperature) between the regression equation to compare the linear regression and quadratic regression fitting degree, investigate Then, the quadratic regression equation was optimized by MATLAB software to get the optimal formula and the predicted value under the constraint conditions, and the experimental verification was carried out. The results showed that the correlation coefficient of quadratic regression equation was 0.999997, which was significantly better than the linear regression result of R = 0.795144. There was interaction between each factor on the three indicators and the most significant single factor and influence sequence on each index As follows: the conversion rate of initiator dosage> dispersion medium polarity, the size of the particle size stabilizer amount> temperature> monomer concentration of butyl acrylate> initial monomer total mass; the particle size distribution of dispersion medium polarity> Stabilizer concentration> temperature. The errors between the predicted value and the experimental value obtained by the quadratic regression equation in the optimal formulation were: conversion rate | ΔK | <0.6%, average particle size | △ (?) | <6%, particle dispersion | Δε | <30%.