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作者曾报道良性肝病时上升的AFP 与肝细胞癌(HCC)时升高的AFP 在其糖链结构上有不同之处,这对鉴别HCC 和良性肝病两者是有用的。今报道岩藻糖苷AFP 的测定对HCC 早期诊断的意义。对象是AFP 阳性的243例HCC 和血管造影、图像诊断所确诊的114例良性肝病患者(肝硬化58例、慢性肝炎43例、急性肝炎13例)、共357例。其中最大肿瘤直径3cm 以下的有37例、2cm 以下者16例。通过交叉亲合性免疫电泳测定岩藻糖苷AFP。HCC 组中岩藻糖苷AFP 的比率[岩藻糖苷指数(Fucosylation),FI;43±32%]比良性肝病组(4±7%)显著升高(P<0.001)。同时,59例(24%)HCC 病例的血清AFP 值低于400ng/ml,
The authors have reported that elevated AFP in benign liver disease differs from its elevated sugar chain structure in hepatocellular carcinoma (HCC) in terms of its sugar chain structure, which is useful for identifying both HCC and benign liver disease. The significance of the determination of fucoside AFP in early diagnosis of HCC is reported here. The subjects were 243 cases of AFP positive HCC and 114 cases of benign liver disease diagnosed by angiography and image diagnosis (58 cases of liver cirrhosis, 43 cases of chronic hepatitis, 13 cases of acute hepatitis), and a total of 357 cases. Among them, 37 cases had a maximum tumor diameter of 3 cm or less, and 16 cases had a tumor size less than 2 cm. The fucosyl-AFP was determined by cross-affinity immunoelectrophoresis. The ratio of fucoside AFP in the HCC group [Fucosylation, FI; 43±32%] was significantly higher than in the benign liver disease group (4±7%) (P<0.001). At the same time, the serum AFP value was lower than 400ng/ml in 59 cases (24%) of HCC cases.