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大部份急性肾炎的发病过程是由免疫复合物引起补体活化,释放出化学趋化因子和过敏毒素,吸引白细胞,破坏肾小球基底膜和细胞,可见急性肾炎与补体活化有很大关系,祖国医学用中药治疗急性肾炎积累了丰富的经验,对近十余年发表的中医治疗急性肾炎的有效方剂分析,发现许多方剂都有麻黄,实验证明麻黄中有强烈抑制补体溶血活性的物质存在;其可能机制之一是抑制C_3转化酶EAC142形成;这一物质不是麻黄硷,是一种在pH8.5沉淀,于pH7.0溶解的物质。
Most of the pathogenesis of acute nephritis is complement activation caused by immune complexes, release of chemical chemokines and anaphylatoxins, attract white blood cells, destroy the glomerular basement membrane and cells, showing that acute nephritis has a lot to do with complement activation, Chinese medicine has accumulated rich experience in the treatment of acute nephritis with traditional Chinese medicine. Analysis of the effective prescriptions of traditional Chinese medicine for treating acute nephritis published in the past decade has found that many prescriptions have ephedra. Experiments have shown that there are substances that strongly inhibit the hemolytic activity of complement in ephedra; One of its possible mechanisms is the inhibition of the formation of the C3 converting enzyme EAC142; this substance is not ephedra, a substance that precipitates at pH 8.5 and dissolves at pH 7.0.