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目的 探讨川芎嗪对新生儿缺氧缺血性脑病 (HIE)脑组织的保护作用。方法 47例HIE患儿随机分为Ⅰ组 (n =2 3)和Ⅱ组 (n=2 4) ,两组均给一般治疗的同时 ,Ⅰ组加用川芎嗪治疗。治疗前后分别测定血浆神经元特异性烯醇化酶 (NSE)和红细胞总钙量 (EryCaT)作为观察指标。并以 2 0例正常新生儿作健康对照组。结果 Ⅰ组NSE治疗前 38.2 0± 14.82ng L、后 11.19±3.97ng L ;EryCaT治疗前 5 .19± 1.12ng L、后 3.95± 1.5 1ng L。治疗前后自身对照比较均有显著性差异 ,P均 <0 .0 1。Ⅱ组NSE治疗前 37.19± 13.91ng L、后 33.79± 9.37ng L ;EryCaT治疗前 5 .2 1± 1.0 1ng L、后 4.98± 1.2 3ng L。治疗前后自身对照比较无显著性差异。P均 >0 .0 5。治疗后Ⅱ组和Ⅰ组比较NSE、EryCaT均有显著性差异。P均 <0 .0 1。结论 川芎嗪对HIE新生儿脑组织有保护作用 ,其机制可能和阻止钙离子内流有关。
Objective To investigate the protective effect of ligustrazine on neonatal hypoxic-ischemic encephalopathy (HIE) brain. Methods Forty-seven children with HIE were randomly divided into group Ⅰ (n = 23) and group Ⅱ (n = 24). Both groups were given general treatment while group Ⅰ was treated with ligustrazine. Plasma neuron specific enolase (NSE) and total erythrocyte calcium (EryCaT) were measured before and after treatment as indicators. Twenty healthy normal newborns were used as healthy control group. Results The NSE before treatment in group Ⅰ was 38.2 ± 14.82ng L, followed by 11.19 ± 3.97ng L; before EryCaT treatment, 5.119 ± 1.12ng L and 3.95 ± 1.5 1ng L after treatment. Before and after treatment compared with their own control were significantly different, P <0.01. Group Ⅱ NSE before 37.19 ± 13.91ng L, after 33.79 ± 9.37ng L; EryCaT before treatment 5.21 ± 1.0 1ng L, after 4.98 ± 1.2ng 3ng. Before and after treatment compared with their own no significant difference. P> 0 .0 5. There was significant difference between NSE and EryCaT in group Ⅱ and group Ⅰ after treatment. P <0. Conclusion Tetramethylpyrazine has a protective effect on brain tissue of HIE neonates, and its mechanism may be related to preventing calcium influx.