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目的研究单磷酸阿糖腺苷治疗慢性乙型肝炎的临床疗效。方法选择189例慢性乙型肝炎患者,分别单独应用单磷酸阿糖腺苷联合胸腺肽、乙肝疫苗、阿昔洛韦、自体LAK细胞回输5个治疗组,并以抗乙肝免疫核糖核酸作对照,评估各组肝功能和HBV复制近、远期疗效。结果不论单独应用单磷酸阿糖腺苷或联合其它药物及疗法治疗慢性乙型肝炎,ALT复常率、HBeAg、HBVDNA转阴率近、远期疗效均高于对照组(P<0.01),但以联合胸腺肽、自体LAK细胞回输治疗组效果最佳。结论肯定了单磷酸阿糖腺苷治疗慢性乙型肝炎降酶、抗乙肝病毒的效果,联合组优于对照组
Objective To study the clinical efficacy of adenosine monophosphate in the treatment of chronic hepatitis B patients. Methods A total of 189 patients with chronic hepatitis B were selected and treated with adenosine monophosphate plus thymosin, hepatitis B vaccine, acyclovir and autologous LAK cells respectively. Five anti-hepatitis B immunosorbent RNA (RNAi) Assessment of liver function and HBV replication in each group, long-term efficacy. Results Whether treated with vidarabine alone or in combination with other drugs and therapies for treatment of chronic hepatitis B, ALT normalization rate, HBeAg and HBVDNA negative conversion rate were both close and long-term effects were higher than those in the control group (P <0.01) In combination with thymosin, autologous LAK cells returned to the treatment group the best. Conclusions Affirmed monotherapy with adenosine monophosphate treatment of chronic hepatitis B, anti-hepatitis B virus effect, the combined group was better than the control group