目的以挤压大鼠颈总动脉造成血管损伤 ,观察猪十二指肠类肝素 (冠心舒 )对血管损伤后再狭窄的防治作用。方法 6 0只大鼠随机分为 5组 ,即病理模型组 ,低、中、高剂量冠心舒组及阿司匹林对照组。术前 1周开始灌服药物 ,每天 1次 ,共 4周。术后 3周 ,在光镜下以显微测微计测量、计算内膜增生程度。结果病理模型组 (不给药 )血管内膜横切面积占有率明显增大 ,管腔面积占有率明显缩小 ;与病理模型组比 ,给冠心舒动物血管内膜横切面积剂量依赖地明显缩小 ,管腔面积占有率明显增大 ,并有抑制平滑肌细胞转型及促内皮修复作用。结论冠心舒有抗大鼠颈总动脉挤压伤后再狭窄作用 Objective To squeeze the rat common carotid artery to cause vascular damage and to observe the pig duodenal heparin (Guan Xin Shu) on the prevention and treatment of vascular injury after restenosis. Methods Sixty rats were randomly divided into five groups: pathological model group, low, medium and high dose Guanxin Shu group and aspirin control group. One week before surgery, the drug was given orally, for 4 weeks. Three weeks after surgery, the degree of neointimal hyperplasia was calculated by microscopic micrometer measurement under light microscope. Results Compared with the pathological model group, the cross-sectional area of ​​the intima in the model group was significantly increased and the lumen area occupancy rate was significantly decreased. Compared with the pathological model group, the cross-sectional area of ​​the intima of the coronary heart disease group was significantly dose-dependently Reduce the lumen area occupancy increased significantly, and inhibit the smooth muscle cell transformation and promote endothelial repair. Conclusion Guanxin Shu anti-stenosis rat carotid artery crush injury