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目的:观察枸橼酸氯米芬抵抗的多囊卵巢综合征患者使用中药联合来曲唑治疗的效果。方法:52例对枸橼酸氯米芬抵抗的多囊卵巢综合征患者随机分为两组,治疗组26例采用中药联合来曲唑治疗,对照组26例采用来曲唑治疗。观察记录卵泡发育、注射人绒毛膜促性腺激素日子宫内膜厚度、血清雌二醇(E2)水平、宫颈粘液评分、排卵率、妊娠率、流产率等指标,比较疗效。结果:两组卵泡发育、子宫内膜厚度、血清雌二醇(E2)水平、宫颈粘液评分差异无显著性。两组排卵率、妊娠率比较差异有显著性。结论:中药联合来曲唑治疗枸橼酸氯米芬抵抗的多囊卵巢综合征患者的疗效优于单纯的来曲唑治疗。
OBJECTIVE: To observe the curative effect of traditional Chinese medicine combined with letrozole in patients with polycystic ovary syndrome who are resistant to clomiphene citrate. Methods: Fifty-two patients with polycystic ovary syndrome resistant to clomiphene citrate were randomly divided into two groups. Twenty-six patients in the treatment group received traditional Chinese medicine plus letrozole, and 26 in the control group received letrozole. Observation of follicular development, injection of human chorionic gonadotropin on endometrial thickness, serum estradiol (E2) level, cervical mucus score, ovulation rate, pregnancy rate, abortion rate and other indicators, to compare the efficacy. Results: There were no significant differences in follicular development, endometrial thickness, serum estradiol (E2) level and cervical mucus score between the two groups. Two groups of ovulation rate, pregnancy rate difference was significant. Conclusion: The effect of traditional Chinese medicine combined with letrozole in the treatment of clomiphene citrate resistance in patients with polycystic ovary syndrome is superior to letrozole alone.