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目的 探讨原发性肝淋巴瘤 (PLL)的临床病理特点及治疗方法。方法 回顾性分析 5例原发性肝淋巴瘤的病因、临床表现、病理特征和治疗结果。结果 5例均有上腹痛及发热 ,3例有淋巴瘤B症状 (发热、盗汗、体重减轻 )。有 3例合并慢性肝炎或肝硬化。组织学检查所有病例均为非霍奇金淋巴瘤。 1例行单纯手术切除 ,3例行手术 +化疗 ,随访生存超过 12个月者 3例。结论 上腹痛、淋巴瘤B症状及血清乳酸脱氢酶增高是PLL的常见表现 ,手术切除和联合化疗是有效的治疗方法。
Objective To investigate the clinicopathological features and treatment of primary hepatic lymphoma (PLL). Methods Retrospective analysis of 5 cases of primary liver lymphoma etiology, clinical manifestations, pathological features and treatment results. Results All 5 cases had upper abdominal pain and fever, and 3 cases had lymphoma B symptoms (fever, night sweats, weight loss). There are 3 cases with chronic hepatitis or cirrhosis. All cases were histologically non-Hodgkin’s lymphoma. One case underwent simple surgical resection, three cases underwent surgery plus chemotherapy, and 3 cases were followed up for more than 12 months. Conclusion The symptoms of upper abdominal pain, lymphoma B and elevated serum lactate dehydrogenase are common manifestations of PLL. Surgical resection combined with chemotherapy is an effective treatment.