论文部分内容阅读
柠檬酸铝是一种较有前途的矽肺防治药物。以往应用生物化学的方法观察到,柠檬酸铝具有抗二氧化硅细胞毒的作用。本文通过扫描电镜观察豚鼠肺泡巨噬细胞表面,又从形态学上研究了柠檬酸铝对二氧化硅细胞毒作用的影响。结果表明,正常豚鼠肺泡巨噬细胞呈圆形或卵圆形,有丰富的不规则折迭和微绒毛突起的不均一表面,有的带有细长伪足;一定剂量的二氧化硅粉尘与巨噬细胞孵育30分钟后,可观察到细胞正在吞噬粉尘,此时细胞表面已有改变,微绒毛消失,折迭明显变浅,孵育3.5小时后,胞体缩小,表面结构消失,呈岩石样外观,有些细胞
Aluminum citrate is a more promising silicosis control drug. Previous biochemical methods have been observed, aluminum citrate has anti-silica cytotoxic effect. In this paper, the surface of guinea pig alveolar macrophages was observed by scanning electron microscopy, and the effect of aluminum citrate on the cytotoxicity of silica was also studied morphologically. The results showed that the alveolar macrophages of normal guinea pigs were round or oval, with irregular surface of irregular fold and microvilli protrusion, some of them with slender pseudopodia; a certain dose of silica dust and Macrophage incubated for 30 minutes, the cells can be observed phagocytosis of dust, the cell surface has been changed, the disappearance of microvilli, fold significantly lighter, 3.5 hours after incubation, the cell body shrinks, the surface structure disappeared, rock-like appearance Some cells