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目的观察抗抑郁治疗对男性稳定型心绞痛伴抑郁患者治疗效果。方法将60例男性稳定型心绞痛伴抑郁的患者随机分为治疗组(n=30,除常规治疗外加用抗抑郁治疗)和对照组(n=30,常规治疗)。于治疗前、治疗后1、3和6个月分别进行临床缺血相关事件和24小时动态心电图观察,计算心肌缺血总负荷(TIB)。结果在治疗最初3个月两组内缺血相关事件发生率和TIB差异无显著意义,治疗6个月后,治疗组缺血事件少于对照组(P<0.005),TIB显著少于对照组(P<0.001)。结论抗抑郁治疗可改善男性稳定型心绞痛伴抑郁患者的心绞痛症状,改善心肌缺血,降低缺血相关事件发生率。
Objective To observe the effect of antidepressant on patients with stable angina and depression. Methods Sixty patients with stable angina pectoris and depression were randomly divided into treatment group (n = 30, except for conventional treatment plus antidepressant treatment) and control group (n = 30, conventional treatment). Clinical ischemic-related events and 24-hour Holter monitoring were performed at 1, 3, and 6 months after treatment, and the total myocardial ischemic load (TIB) was calculated. Results There was no significant difference in the incidence of ischemic related events and TIB between the two groups in the first 3 months of treatment. After 6 months of treatment, the ischemic events in the treatment group were less than those in the control group (P <0.005), and TIB was significantly less than that in the control group (P <0.001). Conclusions Antidepressant therapy can improve angina pectoris, improve myocardial ischemia and reduce the incidence of ischemic related events in patients with stable angina and depression.