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本研究利用灵敏的荧光分光光度法，通过检测正畸矫治患者口腔唾液中亚硝酸盐（NO-2）的含量来间接反映一氧化氮（NO）的水平变化。结果表明，健康青少年组唾液中NO含量无性别差异（P＞0．05），正畸矫治患者组矫治过程中其含量明显高于健康人群（P＜0．01），而保持期患者则与健康人群无显著性差异（P＞0．05）。患者在矫治器作用的第一、二周唾液中NO含量最高，第三、四、五周也明显高于治疗前，固定矫治器矫治组与活动矫治器矫治组无显著性差异（P＞0．05）。本研究揭示了正畸治疗与唾液中NO含量变化的内在联系，唾液NO可能在杀菌防御、维持口腔粘膜完整性以及参与正畸牙周组织改建等方面具有一定的作用。
In this study, sensitive fluorescence spectrophotometry was used to indirectly reflect the level of nitric oxide (NO) by detecting the content of nitrite (NO-2) in oral saliva of orthodontic patients. The results showed that the content of NO in saliva of healthy adolescent group was no significant difference (P> 0.05), while the content of NO in orthodontic treatment group was significantly higher than that of healthy group (P <0.01) No significant difference in healthy population (P> 0.05). In the first and second weeks of treatment, the NO content in saliva was the highest, and the third, fourth and fifth weeks were also significantly higher than those before treatment. There was no significant difference between the fixed appliance group and the active appliance group (P> 0 .05). This study revealed the intrinsic relationship between orthodontic treatment and changes in NO content in saliva. NO in saliva may play a role in bactericidal protection, maintenance of oral mucosal integrity, and involvement in orthodontic periodontal tissue remodeling.