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目的分析小儿毛细支气管炎发展成为支气管哮喘的危险因素。方法根据随访期内是否发生支气管哮喘,将286例患儿分为哮喘组和非哮喘组,比较两组在性别、年龄、哮喘家族史、喂养方式、卡介苗接种、免疫球蛋白使用等方面的差异。结果单因素分析和多因素分析结果均表明哮喘家族史、过敏体质、接种卡介苗情况、使用免疫球蛋白情况、母乳喂养是毛细支气管炎发展为支气管哮喘的显著因素(P<0.001)。结论合理使用免疫球蛋白、积极接种卡介苗、倡导母乳喂养可以降低毛细支气管炎发展成支气管哮喘的风险。
Objective To analyze the development of pediatric bronchiolitis as a risk factor for bronchial asthma. Methods According to whether bronchial asthma occurred during the follow-up period, 286 children were divided into asthma group and non-asthma group. The differences in gender, age, family history of asthma, feeding mode, BCG vaccination and immunoglobulin use were compared between the two groups . Results Both univariate analysis and multivariate analysis showed that family history of asthma, allergy, BCG vaccination, immunoglobulin use and breastfeeding were significant factors in the development of bronchiolitis as bronchial asthma (P <0.001). Conclusion The rational use of immunoglobulins, active BCG vaccination, advocacy of breastfeeding can reduce the development of bronchiolitis bronchial asthma risk.