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目的:探讨阿司匹林联合氯吡格雷治疗不稳定型心绞痛临床效果。方法:选取我院2012年7月-2013年6月不稳定型心绞痛患者200例,其中88例设置为对照组,在常规治疗基础上应用阿司匹林;观察组112例,在对照组基础上联合应用氯吡格雷治疗。结果:观察组效果评分为3.87±0.03,高于对照组3.24±0.05(P<0.05);观察组心绞痛持续时间和心绞痛发作频率分别为3.18±0.03 min和1.39±0.02次/d,均低于对照组3.62±0.07 min和2.81±0.03次/d(P<0.05);观察组血浆黏度、红细胞压积和红细胞聚积指数分别为0.78±0.02 P a o s,0.33±0.02 L/L和7.13±0.04(P<0.05),均低于对照组(P<0.05);两组结果比较差异均有统计学意义(P<0.05);两组不良反应结果比较差异均无统计学意义(P>0.05)。结论:阿司匹林联合氯吡格雷治疗不稳定型心绞痛疗效确切,可以进一步提高患者血流变学指标。
Objective: To investigate the clinical effect of aspirin plus clopidogrel in the treatment of unstable angina pectoris. Methods: 200 cases of unstable angina pectoris in our hospital from July 2012 to June 2013 were selected, of which 88 cases were set as the control group, aspirin was used on the basis of routine treatment, 112 cases in the observation group were used on the basis of the control group Clopidogrel treatment. Results: The effect score of the observation group was 3.87 ± 0.03, which was higher than that of the control group (3.24 ± 0.05) (P <0.05). The duration of angina pectoris and the frequency of angina pectoris in the observation group were 3.18 ± 0.03 and 1.39 ± 0.02 times / d, Control group 3.62 ± 0.07 min and 2.81 ± 0.03 times / d (P <0.05). The plasma viscosity, hematocrit and erythrocyte accumulation index in observation group were 0.78 ± 0.02 P aos, 0.33 ± 0.02 L / L and 7.13 ± 0.04 P <0.05), which were lower than those in the control group (P <0.05). There was significant difference between the two groups (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion: Aspirin plus clopidogrel is effective in treating unstable angina pectoris, which can further improve the hemorheology indexes of patients.