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目的分析利培酮用药后不良反应的规律和特点。方法选取2010年1月—2016年12月800例使用利培酮的精神分裂症患者作为观察对象,观察不良反应的发生率以及表现和特点,并采取相应的处理措施。计数资料采用χ~2检验,P<0.05为差异有统计学意义。结果 800例使用利培酮患者中仅有56例出现不良反应,其中男性30例,女性26例,平均年龄为(42.6±10.5)岁;主要不良反应为锥体外系反应、睡眠障碍、体重增加、心血管系统反应以及内分泌异常,少数患者出现血液系统、胃肠系统反应及其他不良反应。经对症处理后症状缓解。通过分析发现,不良反应的发生与患者的年龄、用药量、用药时间、过敏史、合并用药等因素有关,对比差异均有统计学意义(均P<0.05)。结论临床中需要重视利培酮的合理使用,医护人员需要加强对患者用药的监督,避免不良反应的发生。
Objective To analyze the regularities and characteristics of adverse reactions after risperidone treatment. Methods From January 2010 to December 2016, 800 cases of schizophrenia patients receiving risperidone were selected as the observation objects. The incidence of adverse reactions, their manifestations and characteristics were observed and the corresponding treatment measures were taken. Counting data using χ ~ 2 test, P <0.05 for the difference was statistically significant. RESULTS: Of the 800 patients treated with risperidone, only 56 patients developed adverse reactions, including 30 males and 26 females, with an average age of (42.6 ± 10.5) years. The major adverse reactions were extrapyramidal reactions, sleep disorders, weight gain , Cardiovascular response and endocrine abnormalities, a small number of patients with hematological, gastrointestinal and other adverse reactions. After symptomatic treatment of symptoms. Through the analysis found that the occurrence of adverse reactions and the patient’s age, dosage, medication time, history of allergies, combined medication and other factors, the differences were statistically significant (P <0.05). Conclusions The rational use of risperidone should be emphasized in clinical practice. The medical staff need to strengthen the supervision of patients’ medication and avoid the occurrence of adverse reactions.