目的　调查湛江市肠易激综合征 (IBS)的病因因素。方法　采用病例对照研究方法 ,对2 0 7例IBS病人与同时期在同所医院体检的“健康人”进行流行病学调查和致病多因素探讨。结果　经logistic多因素分析表明 ,有植物神经紊乱及有癔病或精神病家族史与IBS关系最密切 ,OR值分别是 4、3倍。负性事件、长期服抗生素、工作紧张状态、食地瓜木薯也与IBS关系密切 ,OR值分别为 2、1倍。结论　表明以上 6种因素与湛江市IBS的发生有关 Objective To investigate the etiological factors of irritable bowel syndrome (IBS) in Zhanjiang. Methods A case-control study was conducted to investigate the epidemiological and pathogenic factors of 2 0 7 IBS patients and “healthy people” in the same hospital during the same period. Results Logistic multivariate analysis showed that autonomic disorders and rickets or family history of psychosis had the closest relationship with IBS with OR values ​​of 4 and 3 times, respectively. Negative events, long-term antibiotics, work stress, eating sweet potato cassava and IBS are also closely related, OR values ​​were 2,1 times. Conclusions show that the above six factors related to the occurrence of IBS in Zhanjiang City