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VLDL的主要功能是运输内源性甘油三脂(TG)。由肝脏会成,为球形颗粒、其核心含TG和胆固醇酯(CE)、表面含磷脂、自由胆固醇(Ch)和载脂蛋白、包括载脂蛋白B、E和C’S及少量A和D。关于其在血清中的代谢途径及其与其他脂蛋白的关系尚不十分清楚。近年Eisenberg等提出一颇令人注目的假设:即VLDL在代谢过程中其核心部分被脂蛋白脂肪酶(LPL)水解后,体积逐渐变小由VLDL→IDL→LDL。过剩的表面层则可形成类似新生的高密度脂蛋白(HDL),后者在卵磷脂-胆固醇脂酰基转移酶的作用下转变成球形的HDL,成为血浆中HDL的主要来源之一。
The main function of VLDL is to transport endogenous triglycerides (TG). The liver is made up of spherical particles with a core of TG and cholesteryl ester (CE) and a phospholipid, free cholesterol (Ch) and apolipoprotein on the surface, including apolipoproteins B, E and C’S and small amounts of A and D. About its metabolic pathway in serum and its relationship with other lipoproteins is not yet clear. In recent years, Eisenberg et al put forward a rather striking hypothesis: VLDL gradually becomes smaller in volume from VLDL → IDL → LDL after its core part is hydrolyzed by lipoprotein lipase (LPL). Excess superficial layers form newborn high-density lipoproteins (HDLs), which transform into spherical HDLs by lecithin-cholesterol acyltransferases and become one of the major sources of HDL in plasma.