论文部分内容阅读
[目的]观察内镜下植入缓释化疗粒子治疗晚期食管癌的临床疗效。[方法]选取13例晚期食管癌导致的食管管腔梗阻的患者行内镜下植入5-氟尿嘧啶(5-FU)缓释粒子治疗,每个植入点植入5～6粒,观察患者治疗后症状及梗阻缓解情况及近期疗效。[结果]全部病例均顺利完成治疗,未发生出血、穿孔等并发症;肝、肾功能及血常规检查未见异常。13例治疗前吞咽困难分级示Ⅱ级5例、Ⅲ级8例,治疗后Ⅱ级5例全部转为Ⅰ级,Ⅲ级8例中转为Ⅰ级、Ⅱ级各3例;13例中完全缓解0例,部分缓解7例,病情稳定4例,2例无缓解,平均有效率为84.6%。[结论]晚期食管癌管腔梗阻的患者行内镜下植入5-FU缓释粒子治疗,是一种安全有效、毒副作用少、耐受性好的姑息治疗方法。
[Objective] To observe the clinical effect of endoscopic implantation of sustained release chemotherapy particles in the treatment of advanced esophageal cancer. [Methods] Thirteen patients with esophageal obstruction caused by advanced esophageal cancer were treated with 5-fluorouracil (5-FU) sustained-release particles endoscopically. Five to six implants were implanted at each implantation site. Patients were observed Symptoms and obstruction after treatment to alleviate the situation and the recent efficacy. [Results] All cases were successfully treated without bleeding, perforation and other complications; liver, kidney function and blood tests showed no abnormalities. Thirteen patients with dysphagia before treatment showed Grade II in 5 cases and Grade III in 8 cases. After treatment, Grade II in 5 cases all turned into Grade I, Grade III in 8 cases converted to Grade I and Grade II in 3 cases, and in 13 cases, 0 cases, partial remission in 7 cases, stable condition in 4 cases, 2 cases without remission, the average effective rate was 84.6%. [Conclusion] Endoscopic implantation of 5-FU sustained-release particles in patients with advanced esophageal luminal obstruction is a safe and effective palliative treatment with less toxic and side effects.