小鼠0.6mg/10g灌胃朱砂不能产生明显的催眠、镇静和抗惊厥作用;长期连续给予含朱砂的药剂不能使阈下剂量的异戊巴比妥钠引起小鼠入睡,但能使催眠剂量的异戊巴比妥钠催眠时间延长(P<0.05)。小鼠长期给予朱砂后在肝、肾等脏器内都可检出一定量的汞。正常饲养的小鼠体内则不能检出。因此,朱砂作为内服药物的实用价值和潜在毒性应重新考虑。 Mice 0.6mg/10g gavage cinnabar does not produce significant hypnotic, sedative, and anticonvulsant effects; long-term continuous administration of cinnabar-containing agents does not cause the subthreshold dose of isopentartal sodium to cause mice to fall asleep, but can cause hypnotic doses The isome penicillin sodium extended hypnosis time (P<0.05). After long-term administration of cinnabar, mice can detect a certain amount of mercury in liver, kidney and other organs. Can not be detected in normal feeding mice. Therefore, the practical value and potential toxicity of cinnabar as an internal medicine should be reconsidered.