论文部分内容阅读
目的了解甘肃省内脑胶质瘤治疗情况,并与当前所用诊断和治疗指南对比,分析存在的差异。方法收集2011年1月至2014年1月在兰州大学第二医院和甘肃省肿瘤医院治疗的脑胶质瘤患者临床资料,分析胶质瘤患者的年龄、性别、部位的分布特征及手术、放化疗方案等治疗情况。结果共收集脑胶质瘤病例105例,治疗方案均为手术和放化疗,化疗方案有TMZ和VP方案。其中59.0%(62/105)的患者接受化疗,69例高级别胶质瘤(HGG)患者中,有72.6%(45/69)的患者接受了化疗,而接受化疗的HGG患者中仅有40.0%(18/45)采用TMZ方案,60.0%(27/45)的患者采用VP方案(χ2=2.583,P<0.05),而指南中强烈推荐术后应行辅助放化疗。结论当前甘肃省内胶质瘤在化疗方案上与指南中推荐差异甚大,建议临床医生在我国指南的指导下,应尽可能做到“个体化治疗,规范化实施”。
Objective To understand the treatment of glioma in Gansu Province and to compare with the current guidelines for diagnosis and treatment to analyze the differences. Methods The clinical data of patients with glioma treated at Lanzhou University Second Hospital and Gansu Provincial Cancer Hospital from January 2011 to January 2014 were collected. The age, gender, site distribution and operation of glioma patients were analyzed. Chemotherapy and other treatment. Results A total of 105 cases of glioma were collected. The treatment regimens were both operation and radiotherapy and chemotherapy. TMZ and VP regimens were used in the chemotherapy regimens. Of these, 59.0% (62/105) of the patients received chemotherapy, and 72.6% (45/69) of 69 patients with high-grade gliomas (HGG) underwent chemotherapy, compared with 40.0% of patients receiving HGG % (18/45) with TMZ program, 60.0% (27/45) of patients with VP regimen (χ2 = 2.583, P <0.05), while the guidelines strongly recommend adjuvant radiotherapy and chemotherapy after surgery. Conclusions Currently, there are great differences between GAC and GAC in the guideline of chemotherapy. It is suggested that under the guidance of our country guidelines, clinicians should try their best to achieve individualized treatment and standardized implementation.