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目的:探讨趋化因子受体4(CXCR 4)和血管内皮生长因子C(VEGF-C)在人非小细胞肺癌(N SCLC)组织中的表达及其与淋巴结转移的关系。方法:应用免疫组化SP法检测103例N SCLC和20例癌旁正常肺组织中CXCR 4和VEGF-C的表达。结果:CXCR 4和VEGF-C的表达与N SCLC患者的临床分期及有无淋巴结转移密切相关(P<0.05),而与患者的性别、年龄、肿瘤大小、肿瘤分化程度和组织学类型无关(P>0.05)。CXCR 4阳性表达与VEGF-C阳性表达呈显著正相关(P<0.05)。结论:CXCR 4和VEGF-C的表达可作为评估N SCLC转移与复发的一个观测指标。
Objective: To investigate the expression of chemokine receptor 4 (CXCR4) and vascular endothelial growth factor C (VEGF-C) in human non-small cell lung cancer (N SCLC) and their relationship with lymph node metastasis. Methods: The expression of CXCR4 and VEGF-C in 103 cases of N-SCLC and 20 cases of adjacent normal lung tissues were detected by immunohistochemical SP method. Results: The expressions of CXCR4 and VEGF-C were closely related to the clinical stage and lymph node metastasis of patients with N SCLC (P <0.05), but not with the gender, age, tumor size, tumor differentiation and histological type P> 0.05). There was a significant positive correlation between CXCR4 positive expression and VEGF-C positive expression (P <0.05). Conclusion: The expressions of CXCR4 and VEGF-C can be used as an index to evaluate the metastasis and recurrence of N SCLC.