一些临床及实验观察提示,脓毒症早期血液动力学的高动力型反应可由感染灶引起,而晚期的低动力型反应则由于细菌或毒素直接入血而产生。本实验研究设计及结果如下:实验方法将空腹、混种、体重11～19kg的猪分为三组,性别不计,每组5～6头。组Ia:静脉输注活大肠杆菌(无感染病灶)。6头猪肌注硫喷妥钠及静注戊巴比妥钠麻醉后,作气管内插管,接呼吸器。吸入笑气3.5L/min,使之维持轻度全麻。插入的 Some clinical and experimental observations suggest that the early haemodynamic high-kinetic response to sepsis may be caused by the foci of infection, whereas the late low-power response occurs as a direct result of bacterial or toxin into the bloodstream. The experimental design and results are as follows: Experimental methods will be fasting, mixed, weight 11 ~ 19kg pigs are divided into three groups, regardless of gender, each group of 5 to 6 head. Group Ia: Intravenous live E. coli (no infectious lesions). 6 pigs intramuscular injection of thiopental and intravenous sodium pentobarbital anesthesia for endotracheal intubation, then respirator. Inhalation of nitrous oxide 3.5L / min, to maintain mild general anesthesia. Inserted