L α 氨基酸和D α 氨基酸可与五氯化磷直接发生磷酰化反应 ,随后自组装成多肽 ,但 β 氨基酸不能成肽 ,DL α 氨基酸成肽困难 ;在SOCl2 存在下 ,α 氨基酸也不能成肽 .用电喷雾质谱研究了氨基酸的自组装反应 .反应过程中有五元环状的氨基酸五配位磷中间体生成 ,使用硅烷基保护的氨基酸 ,在 3 1PNMR中可观察到五配位磷中间体 . Lα amino acids and Dα amino acids can be directly phosphorylated with phosphorus pentachloride, and then self-assemble into peptides. However, β-amino acids can not be peptides, and DLα-amino acids are difficult to peptide. In the presence of SOCl2, α-amino acids can not Peptide. The self-assembly of amino acids was studied by electrospray ionization mass spectrometry. Five-membered ring-shaped amino acid pentacoordinated phosphorus intermediates were generated during the reaction. The 5 -position phosphates Intermediate.