肥胖与心力衰竭的发生存在着密切的关系。肥胖患者的脂肪移动信号失调,导致非脂肪组织如心肌也出现脂质累积。心脏因脂肪酸过度供应,发生不充分氧化,中间产物如神经酰胺等的累积,导致线粒体功能不全、解偶联、无效循环及活性氧簇的生成,继而使心脏代谢调控失衡,导致收缩功能不全。 There is a close relationship between obesity and heart failure. Obese patients have dyslipidemia, leading to lipid accumulation in non-adipose tissue, such as myocardium. Heart due to excessive supply of fatty acids, the occurrence of inadequate oxidation, the accumulation of intermediate products such as ceramide, resulting in mitochondrial dysfunction, uncoupling, invalid cycle and generation of reactive oxygen species, followed by imbalance of cardiac metabolism, leading to systolic dysfunction.