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从１９９２年１月～１９９３年８月，采用大剂量卡铂＋５－Ｆｕ治疗局部晚期（Ⅲ、Ⅳ）鼻咽癌４８例，完全缓解（ＣＲ）６例（１２．５％）部分缓解（ＰＲ）３６例（７５．０％），无变化（ＮＣ）６例（１２．５％），有效率（ＣＲ＋ＰＲ）８７．５％（４２／４８）。毒性反应主要是恶心呕吐４５例（Ⅰ级１０例，Ⅱ级３５例），占９３．８％；白细胞下降３６例（Ⅰ级１２例，Ⅱ级２０例）Ⅲ级４例），占７５．Ｏ％；脱发１９例（Ⅰ级９例，Ⅱ级８例，Ⅲ级２例），占３９．６％。
From January 1992 to August 1993, 48 cases of locally advanced (Ⅲ, Ⅳ) NPC were treated with high dose carboplatin + 5-Fu. 6 cases (12.5%) of complete remission (CR) ) 36 cases (75.0%), no change (NC) 6 cases (12.5%), effective rate (CR + PR) 87.5% (42/48). Toxicity was mainly nausea and vomiting 45 cases (grade Ⅰ in 10 cases, Ⅱ grade 35 cases), accounting for 93.8%; leukopenia in 36 cases (Ⅰ grade 12 cases, Ⅱ grade 20 cases) Ⅲ grade 4 cases), accounting for 75%. O%. There were 19 cases of alopecia (grade Ⅰ in 9, grade Ⅱ in 8, grade Ⅲ in 2), accounting for 39.6%.