泛素蛋白酶体通路(UPS)除了介导细胞内蛋白质的降解外,还在细胞周期、基因转录及表达、信号转导、凋亡、抗原提呈和炎症等方面发挥重要的作用。近年来的研究发现,该通路还在心肌病、心力衰竭、缺血再灌注损伤、动脉粥样硬化、血管的再狭窄等心血管疾病方面,起着重要的病理生理作用。本文就近期UPS在心血管疾病方面的进展进行综述如下。 Ubiquitin proteasome pathway (UPS) in addition to mediating the degradation of intracellular proteins, but also in the cell cycle, gene transcription and expression, signal transduction, apoptosis, antigen presentation and inflammation plays an important role. Recent studies have found that this pathway also plays an important pathophysiological role in cardiovascular diseases such as cardiomyopathy, heart failure, ischemia-reperfusion injury, atherosclerosis and vascular restenosis. This article reviews recent advances in cardiovascular disease in UPS as follows.