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以1,3,5-三甲基苯(1,3,5-TMB)作为扩孔剂,对介孔纳米材料MCM-41(mobil company of matter)进行了扩孔改性,采用有机溶剂浸渍法将非水溶性的β-胡萝卜素载入到扩孔后的MCM-41的介孔孔道中,得到了β-胡萝卜素/MCM-41新型载药体系。分别利用TEM,FT-IR,元素分析和低温N2吸附-解吸附对MCM-41以及载药体系进行了表征;研究了载药体系中β-胡萝卜素的最佳载药时间,载药量以及体外稳定性等。通过表征,发现采用水热合成法制备的MCM-41具有良好的球形度,规则的孔径结构;扩孔改性后的MCM-41作为药物载体具有较短的载药时间且药物的载药量有明显提高,并且组装体中β-胡萝卜素的稳定性得到了一定程度的改善。该新型载药体系的研究为β-胡萝卜素的广泛应用提供了新的思路。
The mesoporous nanomaterial MCM-41 (mobil company of matter) was reamed with 1,3,5-trimethylbenzene (1,3,5-TMB) as a pore-expanding agent and impregnated with an organic solvent Method was used to load the non-water-soluble β-carotene into the mesopore of MCM-41 after reaming, and a novel β-carotene / MCM-41 drug loading system was obtained. Characterization of MCM-41 and drug-loaded system by TEM, FT-IR, elemental analysis and N2 adsorption-desorption were carried out. The optimal drug loading time, drug loading and drug loading of β-carotene In vitro stability and so on. Through the characterization, it was found that the MCM-41 prepared by hydrothermal synthesis has a good sphericity and regular pore structure. The reaming modified MCM-41 as a drug carrier has shorter drug loading time and drug loading Significantly improved, and β-carotene stability in the assembly has been improved to some extent. The new drug-loaded system of research for the wide application of β-carotene provides a new idea.