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目的:观察胃肠宁合剂对大鼠胃排空、胃电活动和血浆胃动素含量的影响。方法:12周龄的Wistar大鼠128只随机分为正常对照、多潘立酮(商品名为吗丁啉)对照、胃肠宁小剂量及大剂量4组,每组32只。连续给药6 d后,用比色分光光度法测定胃液体和固体排空功能,用放免法检测其血浆胃动素,在给予上述各组药物的同时,用四道生理记录仪检测大鼠胃十二指肠电活动。结果:正常对照、吗丁啉对照、胃肠宁小剂量及大剂量组的胃液体排空率分别为(8.6±1.5)％、(12.1±2.9)％、(18.6±3.1)％和(22.2±5.8)％,各组间比较差异均有统计学意义(均P<0.05);胃固体排空率分别为(9.2±0.7)％、(12.7±1.2)％、(19.8±3.7)％和(20.0±3.2)％,正常对照组、吗丁啉对照组和胃肠宁小剂量组之间差异均有统计学意义(P<0.05,<0.01),但胃肠宁小剂量组和大剂量组间差异无统计学意义(P>0.05);血浆胃动素含量分别为(149.4±15.8)、(185.1±21.7)、(230.4±12.4)和(298.9±19.5)pg／ml,各组间差异均有统计学意义(P<0.05,<0,01),胃肠平滑肌电活动频率分别为(3.71±0.19)、(4.10±0.35)、(4.70±0.23)和(5.30±0.32)次／min,振幅分别为(3.37±0.46)、(3.864±0.31)、(4.34±0.43)和(5.42±0.53)mV,各组间慢波频率和振幅间差异均有统计学意义(P<0.05,<
OBJECTIVE: To observe the effect of Weichuanning Mixture on gastric emptying, gastric electrical activity and plasma motilin content in rats. METHODS: 128 Wistar rats at 12 weeks of age were randomly divided into normal control, domperidone (trade name morphine) control, gastrointestinal attenuated small dose, and large dose of 4 groups, 32 in each group. Six days after continuous administration, gastric emptying and solid emptying were measured by colorimetric spectrophotometry, and plasma motilin was measured by radioimmunoassay. Rats were treated with four physiological recorders simultaneously with each group of drugs. Gastroduodenal electrical activity. Results: The gastric emptying rate of normal control, motilium control, small and large doses of gastrointestinal tract was (8.6±1.5)%, (12.1±2.9)%, (18.6±3.1)%, and (22.2) ± 5.8)%, there was a statistically significant difference between the groups (all P <0.05); the solid gastric emptying rates were (9.2 ± 0.7)%, (12.7 ± 1.2)%, (19.8 ± 3.7)% and (20.0±3.2)%, there were significant differences between normal control group, domperidone control group and low dose of gastrointestinal tract (P<0.05, <0.01), but the small dose group and large dose of gastrointestinal tract There was no significant difference between groups (P>0.05); plasma motilin levels were (149.4±15.8), (185.1±21.7), (230.4±12.4), and (298.9±19.5) pg/ml, respectively. The differences were statistically significant (P<0.05, <0,01). The frequency of gastrointestinal smooth muscle electrical activity was (3.71±0.19), (4.10±0.35), (4.70±0.23), and (5.30±0.32) times/ The amplitudes of min, amplitudes were (3.37±0.46), (3.864±0.31), (4.34±0.43), and (5.42±0.53) mV, respectively. There was a statistically significant difference in the frequency and amplitude of slow waves between the groups (P<0.05, <