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目的研究活脉饮对动脉粥样硬化的治疗作用。方法2005-03～09对中国医科大学附属第二医院心内科通过股动脉内皮剥脱术和高胆固醇喂养的方法建立的兔动脉粥样硬化模型,观察活脉饮治疗后动脉粥样硬化斑块的范围、血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)及内皮素(ET)、一氧化氮(NO),并与单纯高脂组、辛伐他汀组比较。结果活脉饮高剂量组[12g/(kg·d)]斑块范围较单纯高脂组明显减小(P<0.01),与辛伐他汀组比较差异无显著性(P>0.05),活脉饮低剂量组[g/(kg·d)]与单纯高脂组相比差异无显著性(P>0.05);活脉饮治疗组与辛伐他汀治疗组相比,高活脉饮治疗组的TG与之相当,TC和LDL-C高于辛伐他汀治疗组,但未达到统计学意义。低活脉饮治疗组的TC和LDL-C较辛伐他汀治疗组明显升高(P<0.05),TG亦高于辛伐他汀治疗组,但无统计学意义。与高活脉饮治疗组相比,低活脉饮治疗组TG、TC和LDL-C均较高,但只有LDL-C具有统计学意义(P<0.05)。与高脂饮食组相比,正常饮食组、辛伐他汀治疗组、高活脉饮治疗组和低活脉饮治疗组的NO均较高,但只有高活脉饮治疗组具有统计学意义(P<0.01);上述各组的ET均显著低于高脂饮食组(P<0.01)。活脉饮治疗组与辛伐他汀治疗组相比,NO和ET均有所增高,但无统计学意义。高活脉饮治疗组和低活脉饮治疗组相比前者NO较高且ET较低,但均无统计学意义。结论活脉饮能降低实验性动脉粥样硬化家兔血清TG、TC和LDL-C,改善血脂代谢紊乱,且呈一定程度的剂量依赖性。活脉饮能升高实验性动脉粥样硬化家兔血液中NO,降低ET,且呈剂量依赖性,对血管内皮细胞功能有保护作用。
Objective To study the therapeutic effect of Huoxie Yin on atherosclerosis. METHODS: Atherosclerotic plaques were established in the rabbits with atherosclerotic plaques in the Department of Cardiology of the Second Affiliated Hospital of China Medical University from October 2005 to November 2009. Range, serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and endothelin (ET), nitric oxide (NO), and high-fat groups alone, Simva The statin group was compared. RESULTS Compared with the simvastatin group, there was no significant difference (P>0.05) in the range of plaques in the high-dose group (12g/(kg·d)) of Huoxie-yin group compared with the high-fat group (P<0.01). There was no significant difference between the low-dose group [g/(kg·d)] and the high-fat diet alone (P>0.05). Compared with the simvastatin treatment group, the high-speed pulse drink treatment group The TG of the group was comparable, TC and LDL-C were higher than the simvastatin treatment group, but did not reach statistical significance. Compared with simvastatin treatment group, the TC and LDL-C in the low active pulse drinking group were significantly higher than those in the simvastatin treatment group (P<0.05). TG was also higher than that in the simvastatin treatment group, but it was not statistically significant. Compared with Gaohuoxicao treatment group, TG, TC, and LDL-C were all higher in the low active blood drink group, but only LDL-C was statistically significant (P<0.05). Compared with the high-fat diet group, NO was higher in the normal diet group, the simvastatin treatment group, the Gaohuoxionyin treatment group, and the low-active pulsed drinking group, but only the high-active pulse drink group was statistically significant ( P<0.01); The ET of each group was significantly lower than that of the high-fat diet group (P<0.01). Compared with the simvastatin treatment group, the NO and ET levels in the Huoxie Yin group were increased, but they were not statistically significant. Compared with the former group, the high-speed pulsed drinking group and the low-active pulsed drinking group had higher NO and lower ET, but they were not statistically significant. Conclusion Huoxue Yin can reduce serum TG, TC and LDL-C in rabbits with experimental atherosclerosis, and improve the disorder of blood lipid metabolism, and it is dose-dependent in a certain degree. Huoxue Yin can increase the NO in the blood of rabbits with experimental atherosclerosis and reduce ET, which is dose-dependent and has a protective effect on the function of vascular endothelial cells.